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Other functions of the long-lived protein Klotho

Klotho, named Clotho after the Greek god of fate, is a protein naturally expressed in the tissues of the kidney and brain, circulates through the body in a manner similar to hormones. Klotho participate in several important physiological functions, including regulating insulin signaling and fibroblast growth. Klotho is one long-lived protein, it has the function of prolonging life and improving metabolism. Klotho becomes very popular for its long-lived function, the newest researches show that Klotho also has other magic functions.
long-lived protein Klotho can restore muscle strength
Skeletal muscle's inability to heal after injury is a sign of aging, and new research from the university of Pittsburgh (UPMC) shows that Klotho expression rises sharply in young animals and remains unchanged in older animals.Moreover, by raising Klotho levels in older animals, or mitigating the downstream effects of Klotho defects, the researchers were able to restore muscle regeneration in mice after injury.
long-lived protein Klotho can treat Alzheimer
With the increase of life expectancy and the aging of population, the incidence of Alzheimer gradually increases. The long-lived protein, klotho, can improve the cognitive ability of the brain and improve the aging of the brain, and is expected to be an effective compound in the treatment of Alzheimer. The team, led by Dena Dubal, an associate professor of neurology at the university of California, San Francisco, has shown in several studies in mice that the naturally occurring protein improves cognitive performance in mice with Alzheimer, raising new hopes for treatments for the disease.
long-lived protein Klotho can maintain the blood-brain barrier
Studies have found that the Klotho level in choroid plexus decreases with age, and consumption of Klotho protein increases brain inflammation.The effect on other brain regions was further analyzed.It turns out that individuals with less Klotho protein in the choroid plexus respond more positively to innate immune cells in the brain's memory center when other areas of the body are threatened with infection.Klotho helps maintain the barrier between the brain and the immune system.When this long-lived protein is overused, the brain barrier can be damaged, leading to increased inflammation in the brain.
Anyway, we hope that with the continuous development of science, the long-lived protein Klotho can be applied in daily life to create a better life.

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